Barcelona, Spain: A drug that is already well established as a treatment for infection of the retina in people with AIDS has been shown, for the first time, to sensitise cervical cancer to chemotherapy and radiotherapy without an increase in toxic side-effects. Cidofovir is an anti-viral drug that is effective against several viruses, including the […]
Researchers identify biological indicator of response to new ovarian cancer drug
Barcelona, Spain: Researchers have found a way of identifying which ovarian cancer patients are likely to respond well to a new anti-cancer drug called rucaparib. Results of clinical trials have shown that women with tumours that are sensitive to platinum-based chemotherapy and who carry inherited mutations in the BRCA1/2 genes respond well to rucaparib. But […]
Trial results show treatment-resistant advanced non-small cell lung cancer responds to new drug, rociletinib
Barcelona, Spain: A new drug that targets not only common cancer-causing genetic mutations in patients with non-small cell lung cancer (NSCLC), but also a form of the mutation that causes resistance to treatment, has shown promising results in patients in a phase I/II clinical trial. The research will be presented on Friday at the 26th […]
Patients with advanced papillary kidney cancer respond well to a combination of two existing anti-cancer drugs
Barcelona, Spain: Researchers have found that patients with an advanced form of kidney cancer, for which there is no standard treatment and a very poor prognosis, respond well to a combination of two existing anti-cancer drugs. Dr Ramaprasad Srinivasan, head of the Molecular Cancer Therapeutics Section, Urologic Oncology Branch, of the National Cancer Institute in […]
Galeterone shows activity in a variant form of castration-resistant prostate cancer
Barcelona, Spain: Results from a trial of the anti-cancer drug galeterone show that it is successful in lowering prostate-specific antigen (PSA) levels in men with a form of prostate cancer that is resistant to treatment with hormone therapy (castration-resistant prostate cancer or CRPC). Associate professor Mary-Ellen Taplin, of the Dana-Farber Cancer Institute, Boston, USA, will […]
First demonstration of anti-cancer activity for AG-120, an inhibitor of the IDH1 mutation, in patients with advanced leukaemia
Barcelona, Spain: A phase I trial of the first drug designed to inhibit the cancer-causing activity of a mutated enzyme known as isocitrate dehydrogenase (IDH) 1, which is involved in cell metabolism, has shown clinical activity in patients with advanced acute myeloid leukaemia (AML) with the IDH1 mutation. Professor Daniel Pollyea, M.D. will tell the […]
Damaging legacy: mothers who smoke affect the fertility of their sons
Mothers who smoke while they are pregnant or breast feeding may be damaging the future fertility of their sons, according to new findings from research in mice published online in Human Reproduction [1], one of the world’s leading reproductive medicine journals. The study is the first comprehensive animal model to show the mechanism by which […]
International experts issue plea for better research and education for advanced breast cancer
Breast cancer experts around the world have issued a plea to researchers, academics, drug companies, funders and advocates to carry out high quality research and clinical trials for advanced breast cancer, a disease which is almost always fatal and for which there are many unanswered questions. In the latest international consensus guidelines for the management […]
Do children make you happier? Sustaining a desire for a child after failed fertility treatment is linked to worse mental health
Women who have difficulty accepting the fact that they can’t have children following unsuccessful fertility treatment have worse long-term mental health than women who are able to let go of their desire for children, according to new research. The study published online in Human Reproduction [1], one of the world’s leading reproductive medicine journals, is […]
Everest expedition provides first evidence of effects of altitude on blood pressure monitored over a 24-hour period
An expedition to Mount Everest by Italian researchers has shown for the first time that blood pressure monitored over a 24-hour period rises progressively as people climb to higher altitudes. The researchers also found that while a drug used for lowering blood pressure, called telmisartan, was effective in counteracting the effects of altitude up to […]