People who take an anticoagulant medicine double their risk of an internal bleed if they take a type of painkiller called a non-steroidal anti-inflammatory drug (NSAID) such as ibuprofen, diclofenac or naproxen, according to research published in the European Heart Journal [1]. Anticoagulants are usually prescribed to people who develop a blood clot in the […]
Scientists create cancer patients’ ‘digital twins’ to predict how well treatments may work
Barcelona, Spain: Researchers have shown that they can accurately re-create clinical trials of new treatments using ‘digital twins’ of real cancer patients. The technology, called FarrSight®-Twin, which is based on algorithms used by astrophysicists to discover black holes, will be presented at the 36th EORTC-NCI-AACR [1] Symposium on Molecular Targets and Cancer Therapeutics in Barcelona, […]
New ‘mini-protein’ carries radiation dose directly to tumours without harming healthy tissues
Barcelona, Spain: Researchers have shown for the first time that it is possible for a specially-designed ‘mini-protein’ to deliver a radiation dose directly to tumour cells expressing a protein on their cell surfaces called Nectin-4, which is often found in a number of different cancers. In a study presented at the 36th EORTC-NCI-AACR [1] Symposium […]
Researchers find key genetic mutations in bowel cancer cells that lead to resistance to WRN inhibitors
Barcelona, Spain: Researchers have discovered key mutations in certain cancer cells that make them resistant to WRN inhibitors, a new class of anti-cancer drugs. The yet-to-be-published findings are presented at the 36th EORTC-NCI-AACR [1] Symposium on Molecular Targets and Cancer Therapeutics in Barcelona, Spain. Werner helicase (WRN) inhibitors are already being evaluated in phase I […]
Patients with advanced bladder cancer with alterations in the FGFR3 gene respond well to investigational drug, TYRA-300
First results from SURF301 phase I clinical trial Barcelona, Spain: Patients with advanced bladder cancer that had spread to other parts of the body (metastasised) have responded well in a phase I clinical trial of an investigational drug, TYRA-300. The drug targets changes in the FGFR3 gene that drive tumour growth in about 10%-20% of […]
Treatments used for HER2-positive breast cancers could help patients with rare gastrointestinal cancer
— Trial of tucatinib and trastuzumab also showed benefits for HER2-mutated breast cancer — Barcelona, Spain: Drugs designed to target HER2-postive breast cancer could also benefit some patients with bile duct cancer, according to results of a patient trial presented at the 36th EORTC-NCI-AACR [1] Symposium on Molecular Targets and Cancer Therapeutics in Barcelona, Spain. […]
New drug, WNTinib, delays tumour growth and improves survival in mouse models of children’s liver cancer
Barcelona, Spain: A new drug called WNTinib can delay the growth of tumours and improve survival in hepatoblastoma, a type of liver cancer that occurs in young children. This effect was seen in cancer cells taken from patients and implanted into mice. The researchers are now working on strategies to identify children who may benefit […]
Increase in air pollution corresponds with more patients at the hospital emergency department
Copenhagen, Denmark: Increases in levels of particulate matter in the air, even within World Health Organization guidelines, correspond with an increase in the number of patients going to the hospital emergency department, according to research presented at the European Emergency Medicine Congress. [1] The study found links particularly between air pollution and cases of trauma, […]
Seizures caused by children swallowing medications or illegal substances doubled over 15-year period
Copenhagen, Denmark: New data shows that the number of children suffering a seizure after swallowing medications or illegal substances has doubled between 2009 and 2023 in the US. The findings were presented at the European Emergency Medicine Congress. The most common substances involved in these poisonings include over-the-counter antihistamines, prescription antidepressants and painkillers, and illegal […]
Half of all patients with sepsis die within two years
Copenhagen, Denmark: Half of all patients with sepsis admitted to an emergency medical department died within two years, according to Danish researchers investigating factors that could predict outcomes for these patients. Dr Finn E. Nielsen, a senior scientist in the Department of Clinical Epidemiology at Aarhus University Hospital, Denmark, told the European Emergency Medicine Congress […]