Barcelona, Spain: Colorectal cancer is the second most common cause of cancer-related deaths in the Western world, mainly because it is usually diagnosed too late. Finding ways to identify those people who are at increased risk of developing colon cancer is therefore crucial, a researcher told the annual conference of the European Society of Human Genetics. […]
Category: Genetics
How does obesity cause disease in organs distant from those where fat accumulates? New genetic evidence points the way
Barcelona, Spain: Obesity is on the rise throughout the world, and in some developed countries two-third of the adult population is either overweight or obese. This brings with it an increased risk of serious conditions such as heart disease, stroke, cancer and osteoarthritis. Many of these conditions do not appear to affect the parts of […]
Drug combination improves progression-free survival in melanoma patients regardless of genetic status, age and spread of disease
Vienna, Austria: Patients with advanced melanoma skin cancer survive for longer without their disease progressing if they have been treated with a combination of two drugs, nivolumab and ipilimumab, than with either of these drugs alone. New results show that these patients also do better regardless of their age, stage of disease and whether or […]
Discovery of differences between tumours of younger and older colorectal cancer patients may lead to better treatments
Vienna, Austria: Colorectal cancer (CRC) is on the rise among younger patients. Although some of the younger-onset cases can be explained by hereditary factors, the majority arise spontaneously. Researchers have now found that tumours in younger colorectal cancer patients may be molecularly distinct from those of older patients, and that these differences are related to […]
Genetic screening of brain metastases could reveal new targets for treatment
Vienna, Austria: Unravelling the genetic sequences of cancer that has spread to the brain could offer unexpected targets for effective treatment, according to new research presented to the 2015 European Cancer Congress [1] and published simultaneously in Cancer Discovery [2]. Researchers told the Congress that they found that the original, or primary, cancer in a […]
Discovery of significant genetic differences between breast cancers that relapse and those that do not will lead to better treatment
Vienna, Austria: Although most patients with breast cancer are cured after treatment, in about one in five the cancer will recur, returning either to the same place as the original tumour or spreading to other parts of the body (metastasis). Now, researchers have taken an important step towards understanding why some primary breast cancers return […]
People want access to their own genomic data, even when uninterpretable
Glasgow, United Kingdom: The largest study to date of attitudes towards the use of genomic information shows that the majority of people want access to results from genome sequencing, even if these are not directly related to the condition for which the analysis has been undertaken. This applies even when the data are not health-related […]
Discovery of new genetic mutation in aortic disease allows better diagnosis and brings personalised medicine a step closer
Glasgow, United Kingdom: Thoracic aortic aneurysm and dissection (TAAD), an enlargement or tearing of the walls of the aorta in the chest, is, together with abdominal aortic aneurysms, responsible for about 2% of all deaths in Western countries. The aorta is the largest artery in the body, and carries blood from the heart. About one […]
First national study of non-invasive prenatal testing shows it works and is preferred by high-risk women
Glasgow, United Kingdom: Results from a national study of non-invasive prenatal testing (NIPT) in women at high risk of having a baby with Down’s syndrome have been presented at the annual conference of the European Society of Human Genetics. The Netherlands is the first country in the world to include NIPT in a government supported, […]
Novel genetic mutations may arise during early embryonic development rather than being acquired from the parents’ germline
Glasgow, United Kingdom: New, sophisticated gene sequencing techniques are leading to an increasing understanding of the causes of genetic disease, and can help parents with affected children make informed reproductive choices, according to research presented at the annual conference of the European Society of Human Genetics. Until now, de novo genetic mutations, alterations in a […]