Barcelona, Spain: Preliminary data from a phase I clinical trial of a new drug called NVL-520 for patients with non-small cell lung cancer (NSCLC) and other solid tumours, suggest that it may have the potential to both halt tumour growth by inhibiting a cancer-causing gene change, and to reach cancer cells in the brain, with […]
2022
Targeted lung cancer drug shows promise in phase I/II clinical trial
Barcelona, Spain: Early trials of the targeted drug repotrectinib suggest that it could help treat patients with a certain type of non-small cell lung cancer (NSCLC). The results of the TRIDENT-1 trial, which were presented at the 34th EORTC-NCI-AACR [1] Symposium on Molecular Targets and Cancer Therapeutics in Barcelona, Spain, suggest that repotrectinib could be […]
Anti-cancer drugs, olaparib and adavosertib, work best when given sequentially in patients with advanced tumours driven by DNA damage response mutations: results from Phase Ib STAR clinical trial
Barcelona, Spain: Patients with cancers that are driven by certain mutations occurring in response to DNA damage can be safely treated with two drugs, olparib and adavosertib, if they are given in sequence rather than concurrently. Presenting results from the phase Ib STAR [1] clinical trial to the 34th EORTC-NCI-AACR [2] Symposium on Molecular Targets […]
Experimental drug to treat liver cancer shows evidence of activity with manageable side effects
Barcelona, Spain: A new drug that inhibits an enzyme playing a crucial role in cell division and growth has shown signs of anti-cancer activity with manageable side effects in liver cancer patients who have been treated unsuccessfully previously with up to three lines of treatment. Presenting the findings at the 34th EORTC-NCI-AACR [1] Symposium on […]
AKT inhibitor shows signs of effectiveness in a patient trial matching drugs to tumour gene mutations
Barcelona, Spain: In a trial matching new treatments to cancer patients based on the genetic make-up of their tumours, 22% of the patients treated with the AKT inhibitor drug ipatasertib had their tumours shrink. This included patients with breast cancer and endometrial cancer as well as two rarer forms – anal and salivary gland. In […]
Researchers identify specific alterations in the BRAF gene that may affect response to treatment and survival in adult brain cancers
Barcelona, Spain: Researchers have identified a range of genetic alterations in glioma brain cancers that will help them to understand how different mutations in one particular gene interact with other gene alterations and which ones are more susceptible to targeted treatments in adults. Presenting results from the largest group of glioma patients to date, Dr […]
Liquid biopsies can detect which cancer patients may be at higher risk of developing additional blood cancers
Barcelona, Spain: Researchers have found that liquid biopsies, which are increasingly used in the routine care of patients to identify and monitor the progress of cancer, can also detect a disorder of blood cells that places patients at higher risk of developing blood cancers as well. The findings are presented on Friday at the 34th […]
Results revealed from phase I clinical trial of the first drug to successfully inhibit the MYC gene, which drives many common cancers
Barcelona, Spain: Researchers have found that a drug that targets the key, cancer-causing gene, MYC, has for the first time been able to inhibit the function of the gene in a phase I clinical trial. Until now, no other drug has been able to do this safely and effectively. Presenting preliminary results from the trial […]
Patients waiting for urgent surgery in A&E feel calmer and experience less pain if given a music pillow
Berlin, Germany: Patients waiting in an emergency department for urgent surgery are less anxious, more relaxed and experience less pain if they are given a special music pillow to rest on, according to research presented at the European Emergency Medicine Congress [1]. Ms Lisa Antonsen, a nurse in the Department of Emergency Medicine at Odense […]
Digital technology linking care homes to clinical advice hubs reduces A&E attendances
Berlin, Germany: The use of digital technology in residential care homes can reduce the number of emergency department attendances by 10% each month, according to new research presented at the European Emergency Medicine Congress [1]. Preliminary evidence from a study that modelled the effect of implementing the UK’s National Health Service (NHS) HealthCall digital technology […]